课题组简介

季者，北京大学化学与分子工程学院化学生物学系助理教授，课题组长，博士生导师。课题组面向化学生物学和物理化学的交叉领域，聚焦生物大分子内静电环境对化学键的活化作用，发展新型的金属酶、核酶，开发高效的蛋白共价反应、共价药物，并探索蛋白质机器的生物化学应用。现应课题组建设需求，诚招博士后1-2名。

Research Interests

Within specific protein sites, exceptionally intense electric fields can be found, reaching magnitudes as high as 100 MV/cm, or 10 V/nm. These remarkable electric fields are produced by charges and dipoles held by amino acid residues, peptide backbones, and metal ions. Once the electric fields are projected onto a chemical bond undergoing a reaction, its transition state can be substantially stabilized, leading to rate acceleration by several orders of magnitude.

The Ji lab aims to leverage the power of protein electrostatics to activate chemical bonds that are believed inert and to drive chemical reactions that are often sluggish. We are especially interested in the chemical bonds and the reactions at the interface of chemistry and biology. By combining synthetic chemistry, molecular biology, enzymology, and spectroscopy, we aim to develop novel biocatalysts, medicines, and diagnostics that improve human health.

博士后应聘条件

已经或即将获得化学/生命科学等相关专业的博士学位，发表过高水平研究论文;

热爱科研，对交叉学科问题感兴趣;

踏实肯干，正直诚恳,具有团队合作精神和沟通交流能力。

博士后岗位待遇

提供极具竞争力的薪酬待遇，具体面议。提供北京大学全职博士后的福利待遇，包括但不限于子女入学、住房公积金、养老保险、公费医疗、住房补贴等（详情可参考官网https://postdocs.pku.edu.cn）。

鼓励并支持申请北京大学“博雅”博士后项目（详情可参考https://postdocs.pku.edu.cn/tzgg/22e0746345904184b6576a97f47607e2.htm），和北京分子科学国家研究中心BMSJuniorFellow（详情可参考https://www.chem.pku.edu.cn/zpxx/146429.htm）。2023年度第二批申请截止时间为10月20日。

申请方式

有意者请将个人简历（教育工作经历，研究工作内容简介，发表论文获奖情况，掌握的研究技能，2-3名推荐人联系方式等）发送至邮箱：jizhe@pku.edu.cn，邮件标题请注明“博士后申请+本人姓名” 。初选材料合格者将通知面试。本招聘信息长期有效。

导师简介

季者，2014年本科毕业于清华大学化学系，师从石高全教授。2014至2019年在美国加州大学伯克利分校化学系Omar M. Yaghi教授课题组开展博士研究。2020年至2023年在美国斯坦福大学化学系Steven G. Boxer课题组从事博士后研究。研究成果以第一作者、共同第一作者、和通讯作者身份发表于 Science, Nat. Chem., J. Am. Chem. Soc., PNAS, Angew. Chem., Adv. Mater.等学术期刊。

代表作

(#共同第一作者,*通讯作者)

1.C. Zheng#, Z. Ji#, I. I. Mathews, S. G. Boxer, Enhanced active-site electric field accelerates enzyme catalysis. Nat. Chem., 2023, DOI: 10.1038/s41557-023-01287-x.

2.Z. Ji*, S. G. Boxer*, β-Lactamases evolve against antibiotics by acquiring large active-site electric fields. J. Am. Chem. Soc., 2022, 144, 22289-22294.

3.Z. Ji, J. Kozuch, I. I. Mathews, C. S. Diercks, Y. Shamsudin, M. A. Schultz, S. G. Boxer, Protein electric fields enable faster and longer-lasting covalent inhibition of β-lactamases. J. Am. Chem. Soc., 2022, 144, 20947-20954.

4.N. A. Danaf, W. Schrimpf, P. Hirschle, D. C. Lamb, Z. Ji*, S. Wuttke*, Linker exchange via migration along the backbone in metal-organic frameworks. J. Am. Chem. Soc., 2021, 143, 10541-10546.

5.Z. Ji, T. Li, O. M. Yaghi, Sequencing of metals in multivariate metal-organic frameworks. Science, 2020, 369, 674-680.

6.Z. Ji#, H. Zhang#, H. Liu, O. M. Yaghi, P. Yang, Cytoprotective metal-organic frameworks for anaerobic bacteria. Proc. Natl. Acad. Sci. U.S.A., 2018, 115, 10582-10587.

7.Z. Ji, C. A. Trickett, X. Pei, O. M. Yaghi, Linking molybdenum-sulfur clusters for electrocatalytic hydrogen evolution. J. Am. Chem. Soc., 2018, 140, 13618-13622.